Acide Obeticholike ikoreshwa wenyine cyangwa mu kuvura indwara runaka y'umwijima (primaire biliary cholangitis-PBC).
izina RY'IGICURUZWA | Acide ya Obeticholike |
Izina ryimiti | 6-Ethylchenodeoxycholic aside |
Irindi zina | 3A, 7A -DIHYDROXY-6A -ETHYL-5B-CHOLAN-24-OIC ACID; aside Obeticholike 6-ECDCA; 6alpha-Ethyl-chenodeoxycholic acide; 6-Ecdca; -ECDCA) |
Umubare CAS | 459789-99-2 |
Inzira ya molekulari | C26H44O4 |
Uburemere bwa formula | 420.63 |
Kugaragara | Ifu yera |
Suzuma | 99.0% min |
Ubucucike | 1.091 g / cm3 |
Ingingo yo gushonga | 108-110 ° C. |
Ingingo | 562.9 ± 25.0 ° C. |
Amapaki | 20kg / umufuka / ingoma, 25kg / umufuka / ingoma, cyangwa nkuko ubisabwa |
Ububiko | Bika kontineri ifunze cyane ahantu humye & akonje.Ntugaragaze urumuri rw'izuba. |
COA & MSDS | Birashoboka |
Acide ya Obeticholike ni dihydroxy-5beta-cholanic aside ni chenodeoxycholic aside itwara insimburangingo ya Ethyl kuri 6alpha-umwanya.Acide-sintetike ya acide ikora nka farnesoid X reseptor agonist kandi ikoreshwa mukuvura cholariya yibanze ya biliary.Ifite uruhare nka farnesoid X reseptor agonist hamwe na hepatoprotective agent.Ni dihydroxy-5beta-cholanic aside, 3alpha-hydroxy steroid na 7alpha-hydroxy steroid.Bikomoka kuri acide ya chenodeoxycholic.
Acide Obeticholike (OCA) ni acide ya acide yahinduwe hamwe na agonist ikomeye ya reseptor ya farnesoid X (FXR) ikoreshwa mukuvura indwara zumwijima harimo na cholangite yibanze.
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Kuyobora igihe
≤100kg: mu minsi itatu y'akazi nyuma yo kwishyura.
>100kg: icyumweru kimwe
Icyitegererezo
Birashoboka.
Amapaki
20kg / umufuka / ingoma, 25kg / igikapu / ingoma
cyangwa nkuko ubisabwa.
Ububiko
Bika kontineri ifunze cyane ahantu humye & akonje.
Ntugaragaze urumuri rw'izuba.