Cetylpyridinium chloride nkumuti wa COVID-19

Ubushakashatsi bwerekanye inshuro nyinshi za disinfectant ya quaternary ammonium nkubuvuzi bwa virusi nyinshi, harimo na coronavirus: ibi bikorwa mugukuraho lipide ikingira ikingira virusi nka SARS-CoV-2 zishingiye.Quaternary ammonium ivanze irasabwa cyane kwica virusi kandi hari ibicuruzwa birenga 350 kurutonde rwa EPA N: Imiti yica udukoko kugirango ikoreshwe na SARS-CoV-2 (Ibikoresho byiyongera. imiti iri kurutonde rwa EPA yaravuzwe kandi> 140 irashobora guhagarika virusi muminota mike (18).
Aya makuru yatugejejeho ubushakashatsi bunini bwa ammonium ya quaternary hamwe nibikorwa byo kurwanya coronavirus ndetse no kumenya imiti yamaze gupimwa mu ivuriro kandi ishobora gukoreshwa nk'ubuvuzi bushobora kuvura COVID-19.Imwe mu miti yica udukoko yerekanwe ko yangiza virusi (Ibikoresho by'inyongera) kandi ikoreshwa cyane mu bicuruzwa byita ku muntu ni chloride cetylpyridinium.Uru ruganda ruboneka cyane cyane mu koza umunwa kandi rwashyizwe ku rutonde na FDA nkuko bisanzwe bifatwa nk’umutekano (GRAS) ku buryo runakoreshwa nk'imiti igabanya ubukana bw’inyama n’ibikomoka ku nkoko (kugeza 1%).Cetylpyridinium chloride yakoreshejwe mu bigeragezo byinshi byo kwa muganga, harimo nk'ubuvuzi bwo kwandura indwara z'ubuhumekero bwemeza ko bukoreshwa nka virusi.Cetylpyridinium birashoboka ko itera virusi idakora mugusenya capsid ndetse no mubikorwa byayo bya lysosomotropique, nkuko byavuzwe haruguru, bikunze kugaragara kumyanya ya amonium ya kane.Ibi bitera kwibaza niba bimwe mu biyobyabwenge byagaragaye hamwe nibikorwa bya virusi birwanya SARS-CoV-2 muri vitro bitwara kimwe, aribyo bishobora gusenya virusi capsid kimwe no kwirundanyiriza muri lysosome cyangwa endosomes hanyuma bikabuza kwinjira muri virusi.Ubushakashatsi bwiyongereyeho bwerekanye ko iyi ngaruka ishobora kugereranywa no gukoresha Cathepsin-L inhibitor.

 Cetylpyridinium chloride (CPC)

Quaternary ammonium ivanze nibikorwa bizwi bya coronavirus