Biosynthesis ya Olivetol ni iki?

Olivetol, izwi kandi nka 5-pentylresorcinol, ni ibintu bisanzwe bibaho byitabiriwe cyane mumyaka yashize kubera imiti ishobora gukoreshwa ninganda.Ni molekile ibanziriza biosynthesis yibintu bitandukanye, harimo urumogi ruboneka cyane mubihingwa by'urumogi.Gusobanukirwa biosynthesis yaolivetolni ngombwa kugirango tumenye ubushobozi bwayo kandi ushakishe mubikorwa bitandukanye.

Biosynthesis yaOlivetolitangirana no guhuza molekile ebyiri za malonyl-CoA, zikomoka kuri acetyl-CoA, binyuze mumikorere ya enzyme yitwa polyketide synthase.Iyi reaction ya conensation itera gushiraho urwego ruciriritse rwitwa geranyl pyrophosphate, ikaba ibanziriza ibinyabuzima muri biosynthesis yibicuruzwa bitandukanye, harimo na terpene.

Geranyl pyrophosphate ihindurwamo aside ya olive binyuze murukurikirane rwimikorere.Intambwe yambere ikubiyemo kwimura itsinda rya isoprenyl muri geranyl pyrophosphate kuri molekile ya hexanoyl-CoA, ikora urugimbu rwitwa hexanoyl-CoA olive aside cyclase.Iyi reaction ya cycle izaterwa na enzyme yitwa hexanoyl-CoA: olivelate cyclase.

Intambwe ikurikira muriolivetolbiosynthesis ikubiyemo guhindura hexanoyl-CoA olivetate cyclase muburyo bukora bwitwa tetraketide intermediate.Ibi bigerwaho hifashishijwe urukurikirane rw'imisemburo iterwa na enzymes nka synthase ya chalcone, synthase ya stilbene, na synthase ya resveratrol.Izi reaction ziganisha ku gushiraho abahuza ba tetraketide, hanyuma bigahinduka kuri olivetol nigikorwa cya reductase ya polyketide.

Rimweolivetolni synthèse, irashobora guhindurwa mubindi bintu bitandukanye, harimo urumogi, binyuze mumikorere ya enzymes nka synthase acide urumogi na delta-9-tetrahydrocannabinolic synthase.Iyi misemburo itera guhuzaolivetolhamwe na geranyl pyrophosphate cyangwa izindi molekile zabanjirije gukora urumogi rutandukanye.

Usibye uruhare rwayo muri biosynthesis ya urumogi,olivetolbyagaragaye ko ifite antifungal na antioxydeant.Ubushakashatsi bwerekanye koolivetolIrashobora kubuza imikurire ya virusi zitandukanye ziterwa na fungal, bigatuma iba umukandida utanga ikizere cyo guteza imbere imiti igabanya ubukana.Byongeye kandi,olivetolbyagaragaye ko bifite ibikorwa bikomeye byo gusakara birwanya radicals yubusa, ni molekile ikora cyane ishobora kwangiza ingirabuzimafatizo.Uyu mutungo wa antioxydeant waolivetolirerekana uburyo ishobora gukoreshwa mugutezimbere imiti ivura indwara ziterwa na okiside.

Muncamake, biosynthesis yaolivetolikubiyemo guhuza molekile ya malonyl-CoA, ikurikirwa nuruhererekane rwimikorere ya enzymatique, bikavamo gushirahoolivetol.Uru ruganda rukora nka molekile ibanziriza biosynthesis ya urumogi kimwe nibindi bicuruzwa bisanzwe.Gusobanukirwa inzira ya biosynetike yaOlivetolni ngombwa mugutezimbere ibishoboka mubikorwa bya farumasi ninganda.Ubundi bushakashatsi kuri biosynthesis yaolivetoln'ibiyikomokaho birashobora gutuma havumburwa imiti mishya yo kuvura no gufasha mugutezimbere imiti mishya.